Society of Biological Psychiatry 2026 Conference - NYC
- Audrey KG
- il y a 7 jours
- 2 min de lecture
Dernière mise à jour : il y a 4 jours
Next week, I will be presenting my poster at SOBP 2026 in NYC. So exciting!
This is part of my PhD manuscript, soon to be submitted.
Dissociable effects of subthalamic stimulation on prospective confidence, mood and economic choices
Kist A, Cecchi R, Blouzard E, Pouchon A, Chabardès C, Faivre N, Pereira M, Polosan M*, Bastin J* (* equal contributions as last authors)
Background: Growing evidence implicates the subthalamic nucleus (STN) in value-based decisions. In this study, we examined how stimulation of the associative–limbic STN influences choice behavior, confidence, and mood in individuals with Obsessive-Compulsive Disorder (OCD).
Methods: Using a double-blind, randomized on/off stimulation design in 13 participants, we assessed the causal contribution of the STN. Participants completed a multi-attribute decision-making task in which they accepted or rejected challenges involving variable monetary stakes, alongside repeated confidence and mood ratings.
Results: We found that STN stimulation markedly reduced loss aversion when accounting for temporal fluctuations in choice strategy (mean weight of losses in choice model kl[OFF] = 19.6 ± SEM 2.99, mean kl [ON] = 16.5 ± 2.94, two-sided paired T-test t(12) = 2.28, p = 4.14 × 10-2). Stimulation also had distinct effects on introspective reports: it lowered confidence (mixed model main effect of stimulation on confidence estimate = 3.32 × 10-1 ± 1.59 ×10-1, t(6832) = -2.02, p = 3.71 × 10-1) but elevated mood (mixed model main effect of stimulation on mood estimate = -2.19 × 10-1 ± 1.22 × 10-2, t(6838) = 18.0, p < 10-3 ), suggesting partially independent neural pathways for these judgments. Moreover, STN DBS restored typical relationships between confidence, the magnitude of potential losses, and task difficulty.
Conclusion: Together, these results identify a new role of the STN in shaping prospective confidence and rapid mood dynamics, offering insight into how DBS might alleviate clinically relevant cognitive and affective symptoms in OCD.
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