Society of Biological Psychiatry 2026 Conference - NYC

In April 2026, I have presented no less than 3 posters at the SOBP conference in NYC. So exciting!

Dissociable Effects of Subthalamic Stimulation on Prospective Confidence, Mood and Economic Choices

Kist, A., Cecchi, R., Blouzard, E., Pouchon, A., Chabardes, S., Faivre, N., Bastin, J.**, & Polosan, M.** (2026). 558. Dissociable Effects of Subthalamic Stimulation on Prospective Confidence, Mood and Economic Choices. Biological Psychiatry, 99(10), S339. https://doi.org/10.1016/j.biopsych.2026.03.792

This research is part of my PhD work, and should be submitted anytime soon with the same list of authors.

Background: Growing evidence implicates the subthalamic nucleus (STN) in value-based decisions. In this study, we examined how stimulation of the associative–limbic STN influences choice behavior, confidence, and mood in individuals with Obsessive-Compulsive Disorder (OCD).

Methods: Using a double-blind, randomized on/off stimulation design in 13 participants, we assessed the causal contribution of the STN. Participants completed a multi-attribute decision-making task in which they accepted or rejected challenges involving variable monetary stakes, alongside repeated confidence and mood ratings.

Results: We found that STN stimulation markedly reduced loss aversion when accounting for temporal fluctuations in choice strategy (mean weight of losses in choice model kl[OFF] = 19.6 ± SEM 2.99, mean kl [ON] = 16.5 ± 2.94, two-sided paired T-test t(12) = 2.28, p = 4.14 × 10-2). Stimulation also had distinct effects on introspective reports: it lowered confidence (mixed model main effect of stimulation on confidence estimate = 3.32 × 10-1 ± 1.59 ×10-1, t(6832) = -2.02, p = 3.71 × 10-1) but elevated mood (mixed model main effect of stimulation on mood estimate = -2.19 × 10-1 ± 1.22 × 10-2, t(6838) = 18.0, p < 10-3 ), suggesting partially independent neural pathways for these judgments. Moreover, STN DBS restored typical relationships between confidence, the magnitude of potential losses, and task difficulty.

Conclusion: Together, these results identify a new role of the STN in shaping prospective confidence and rapid mood dynamics, offering insight into how DBS might alleviate clinically relevant cognitive and affective symptoms in OCD.

Poster:

KIST poster SOBP.pdf

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Models:

Models.pdf

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During the conference, I was also among the authors of two other posters presenting my postdoctoral research at UCSF.

Sleep-Aware Adaptive Deep Brain Stimulation to Mitigate Insomnia in OCD

Anderson, E., Guillermo, N., Mohan, L., Kist, A., Kadlec, K., Ray, S., Fan, J. M., Starr, P. A., & Lee, A. M. (2026). 185. Sleep-Aware Adaptive Deep Brain Stimulation to Mitigate Insomnia in OCD. Biological Psychiatry, 99(10), S178. https://doi.org/10.1016/j.biopsych.2026.03.419

This research has already been published in Brain Stimulation, for which I am a co-first author:

Guillermo*, N., Mohan*, L., Kist*, A., Kadlec, K., Anderson, E., Ray, S., Fan, J. M., Starr, P. A., & Lee, A. M. (2026). Sleep-aware adaptive deep brain stimulation to mitigate insomnia in OCD. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 19(1). https://doi.org/10.1016/j.brs.2025.103009

Therapeutic Ventral Capsule DBS for OCD Suppresses Orbitofrontal Electrophysiological Activity

Anderson, E., Kist, A., Sellers, K., Khambhati, A. N., Sugrue, L., Fan, J., Ray, S., Norbu, T., Maya, D. A., Becker, N., Chang, E. F., Starr, P. A., Krystal, A. D., & Lee, A. M. (2026). 556. Therapeutic Ventral Capsule DBS for OCD Suppresses Orbitofrontal Electrophysiological Activity. Biological Psychiatry, 99(10), S338. https://doi.org/10.1016/j.biopsych.2026.03.790

This research should be submitted anytime soon, as a co-first author as well.